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. A new image processing technique is being developed for locating epileptic
seizures sites. The same patient is imaged twice: during and between seizures
using a radiopharmaceutical which tags brain blood flow. The functional SPECT
scans and anatomical MRI 3D data sets are registered using a registration
program developed in our lab. Calculating the difference between the seizure
and non-seizure state yields a functional image which "points" to the origin
of the epileptic seizure. The demo shows the interactive step of registering
two 3D brain images and calculating the transformation matrix from one
coordinate frame (seizure) to the other (non-seizure). Clinical results are
shown. Principal Investigator:
George Zubal.