Lawrence H. Staib Professor of Radiology & Biomedical Imaging, Biomedical Engineering, and Electrical Engineering, Yale University

Research Interests

Automated medical image analysis for measurement, diagnosis and prognosis. Machine learning and model-based methods. Segmentation and nonrigid registration. Applications to cancer, neuroscience and cardiology. Functional magnetic resonance image (fMRI) analysis. Diffusion weighted magnetic resonance (DW-MR) image analysis.

Research on Magnetic Resonance Diffusion Weighted Image Analysis

Research on Meshfree Nonrigid registration Software

Yale Image Processing and Analysis Group

Yale Biomedical Engineering   (listing)

Google Scholar  

Orcid 

Yale Section of Bioimaging   (listing)

BioImage Suite

List of Medical Image Analysis Journals and Proceedings

AIMBE

Academy for Radiology & Biomedical Imaging Research

Selected Publications

• Reference list in bibtex format or RIS format
  
  
• "Parametrically Deformable Contour Models for Image Analysis, " (pdf) L. H. Staib, Ph.D. Dissertation, Yale University, 1990.
  
  
• "Measurement of Left Ventricular Wall Motion from Contour Shape Deformation, " (abstract) R. L. Owen, L. H. Staib, P. Anandan and J. S. Duncan, Information Processing in Medical Imaging , Progress in Clinical and Biological Research, 363:541-556, Wiley-Liss, Inc., New York, 1989.
  
  
• "Measurement of Non-Rigid Motion in Images Using Contour Shape Descriptors, " J. S. Duncan, R. L. Owen, L. H. Staib and P. Anandan, Computer Vision and Pattern Recognition, pages 318-324, IEEE Computer Society Press, Los Alamitos, CA, 1991.
  
  
• "Boundary Finding with Parametrically Deformable Models," (pdf) L. H. Staib and J. S. Duncan, IEEE Transactions on Pattern Analysis and Machine Intelligence, 14(11):1061-1075, 1992.
  
  
• "Deformable Fourier Models for Surface Finding in 3D Images, " (pdf) L. H. Staib and J. S. Duncan, Visualization in Biomedical Computing, 1808:90-104, 1992.
  
  
• "Boundary Finding with Parametrically Deformable Models, " (pdf) L. H. Staib and J. S. Duncan, Advances in Image Analysis, Y. Mahdavieh and R. C. Gonzalez, editors, pages 193-217, SPIE Press, Bellingham, WA, 1992.
  
  
• "Parameterized Feasible Boundaries in Gradient Vector Fields, " M. Worring, A. W. M. Smeulders, L. H. Staib and J. S. Duncan, Information Processing in Medical Imaging, Lecture Notes in Computer Science, 687:48-61, Springer-Verlag, Berlin, 1993.
  
  
• "Deformable Boundary Finding Influenced by Region Homogeneity, " (html) A. Chakraborty, L. H. Staib and J. S. Duncan, Computer Vision and Pattern Recognition, pages 624-627, IEEE Computer Society Press, Los Alamitos, CA, 1994.
  
  
• "An Integrated Approach to Boundary Finding in Medical Images, " A. Chakraborty, L. H. Staib and J. S. Duncan, IEEE Workshop on Biomedical Image Analysis, pages 13-22, IEEE Computer Society Press, Los Alamitos, CA, 1994.
  
  
• "Intermodality 3D Medical Image Registration with Global Search," L. H. Staib and X. Lei, Proceedings of the IEEE Workshop on Biomedical Image Analysis, pages 225-234, IEEE Computer Society Press, Los Alamitos, CA, 1994.
  
  
• "Brain Morphology in Normal and Dyslexic Children: The Influence of Sex and Age," (abstract) R. T. Schultz, N. K. Cho, L. H. Staib, E. L. Kier, J. M. Fletcher, S. E. Shaywitz, D. P. Shankweiler, J. C. Gore, J. S. Duncan and B. A. Shaywitz, Annals of Neurology, 35(6):732-42, 1994.
  
  
• "Parameterized Feasible Boundaries in Gradient Vector Fields," (pdf) M. Worring, A. Smeulders, L. H. Staib, and J. S. Duncan, Computer Vision and Image Understanding, 63(1):135-144, Jan. 1996.
  
  
• "Cardiac SPECT Restoration using MR-based Support Constraints," L. H. Staib and A. Sinusas, Proceedings of the IEEE International Conference on Image Processing , pages 480-483, IEEE Press, Los Alamitos, CA, 1995.
  
  
• "Model-based Deformable Surface Finding for Medical Images," (pdf) L. H. Staib and J. S. Duncan, IEEE Trans. Medical Imaging, 15(5):720-731, 1996.
  
  
• "Deformable Boundary Finding in Medical Images by Integrating Gradient and Region Information," (pdf) A. Chakraborty, L. H. Staib and J. S. Duncan, IEEE Trans. Medical Imaging, 15(6):859-870, 1996.
  
  
• "An Integrated Approach for Surface Finding in Medical Images, " A. Chakraborty, L. H. Staib and J. S. Duncan, IEEE Workshop on Mathematical Methods in Biomedical Image Analysis, pages 253-262, IEEE Computer Society Press, Los Alamitos, CA, 1996.
  
  
• "Magnetic Resonance Imaging-Based Measurement of Hippocampal Volume in Posttraumatic Stress Disorder Related to Childhood Physical and Sexual Abuse - A Preliminary Report, " J. D. Bremner, P. Randall, E. Vermetten, L. H. Staib, R. A. Bronen, C. Mazure, S. Capelli, G. McCarthy, R. B. Innis and D. S. Charney, Biol. Psychiatry, 41:23-32, 1997.
  
  
• "Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-related Posttraumatic Stress Disorder," J. D. Bremner, R. B. Innis, C. K. Ng, L. H. Staib, R. M. Salomon, R. A. Bronen, J. Duncan, S. M. Southwick, J. H. Krystal, D. Rich, G. Zubal, H. Dey, R. Soufer and D. S. Charney, Arch. Gen. Psychiatry, 54:246-254, Mar., 1997.
  
  
• "Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion-Induced Depressive Relapse, " J. D. Bremner, R. B. Innis, R. M. Salomon, L. H. Staib, C. K. Ng, H. L. Miller, R. A. Bronen, J. H. Krystal, J. Duncan, D. Rich, L. H. Price, R. Malison, H. Dey, R. Soufer and D. S. Charney, Arch. Gen. Psychiatry, 54:364-374, April, 1997.
  
  
• "An Integrated Approach for Locating Neuroanatomical Structure from MRI, " (pdf) L. H. Staib, A. Chakraborty, and J. S. Duncan, Int. J. Pattern Recognition and Art. Intell., Invited Paper, Special Issue on Magnetic Resonance Brain Image Analysis, 11(8):1247-1269, Dec. 1997.
  
  
• "Boundary Finding with Correspondence using Statistical Shape Models," (pdf) Y. Wang and L. H. Staib, Computer Vision and Pattern Recognition, pages 338-345, 1998.
  
  
• "Volumetric Layer Segmentation Using Coupled Surfaces Propagation," (pdf) X. Zeng, L. H. Staib, R. T. Schultz and J. S. Duncan, Computer Vision and Pattern Recognition, pages 708-715, 1998.
  
  
• "Review of The Image Processing Handbook, by J. C. Russ," L. H. Staib, J. Nuclear Cardiology, 5:451-452, 1998.
  
  
• "Elastic model based non-rigid registration incorporating statistical shape information," (pdf) Y. Wang and L. H. Staib, Medical Image Computing and Computer-Assisted Intervention, pages 1162-1173, Cambridge, MA, October 1998.
  
  
• "Segmentation and Measurement of the Cortex from 3D MR Images," (pdf) X. Zeng, L. H. Staib, R. T. Schultz and J. S. Duncan. Medical Image Computing and Computer-Assisted Intervention, pages 519-530, LNCS 1496, Springer, Berlin, 1998.
  
  
• "A novel approach for the registration of 2D portal and 3D CT images for treatment setup verification in radiotherapy." (pdf) R. Bansal, L. H. Staib, Z. Chen, A. Rangarajan, J. Knisely, R. Nath, and J. S. Duncan. Medical Image Computing and Computer-Assisted Intervention , LNCS 1496:1075-1086, 1998.
  
  
• "Integrated approaches to non-rigid registration in medical images," (pdf) Y. Wang and L. H. Staib, Workshop on Applications of Computer Vision, pages 102-108, Princeton, NJ, October 1998.
  
  
• "A New Approach to 3D Sulcal Ribbon Finding from MR Images," (pdf) X. Zeng, L. H. Staib, R. T. Schultz, H. Tagare, L. Win and J. S. Duncan. Medical Image Computing and Computer-Assisted Intervention, pages 148-157, LNCS 1679, Springer, Berlin, 1999.
  
  
• "Segmentation and Measurement of the Cortex from 3D MR Images Using Coupled Surfaces Propagation," (pdf) X. Zeng, L. H. Staib, R. T. Schultz and J. S. Duncan, IEEE Transaction on Medical Imaging, Special Issue on Model-based Analysis of Medical Images, 18(10):927-937, Oct. 1999.
  
  
• "Entropy-based, multiple-portal-to-3D CT registration for prostate radiotherapy using iteratively estimated segmentation." (pdf) R. Bansal, L. H. Staib, Z. Chen, A. Rangarajan, J. Knisely, R. Nath, and J.S. Duncan. Medical Image Computing and Computer-Assisted Intervention, LNCS 1679:567-578, 1999.
  
  
• "Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-Compulsive and Attention-Deficit/Hyperactivity Disorders." (pdf) B. S. Peterson, J. F. Leckman, D. Tucker, L. Scahill, L. H. Staib , H. Zhang, R. King, D. J. Cohen, J. C. Gore and P. Lombroso, Arch. Gen. Psychiatry , 57(4):364-372, 2000.
  
  
• "Shape-based 3D Surface Correspondence Using Geodesics and Local Geometry" (pdf) , Y. Wang, B. S. Peterson and L. H. Staib, Computer Vision and Pattern Recognition , 2000.
  
  
• "Boundary finding with prior shape and smoothness models" (pdf) , Y. Wang and L. H. Staib, IEEE Transactions on Pattern Analysis and Machine Intelligence, 22(9), 2000.
  
  
• "Physical model-based non-rigid registration incorporating statistical shape information" (pdf) , Y. Wang and L. H. Staib, Medical Image Analysis, 4:7-20, 2000.
  
  

IEEE Workshop on Mathematical Methods in Biomedical Image Analysis (MMBIA), L. H. Staib, editor, 2001.

• "3D brain surface matching based on geodesics and local geometry," (pdf) Y. Wang, B. S. Peterson and L. H. Staib , Computer Vision and Image Understanding, 89(2-3):252-271, 2003.
  
  
• "Nonlinear estimation and modeling of fMRI data using spatio-temporal support vector regression" (pdf), Y. M. Wang, R. T. Schultz, R. T. Constable and L. H. Staib, Information Processing in Medical Imaging (IPMI'03), pages 647 - 659, July 2003.
  
  
• "Image processing and analysis at IPAG" (pdf) , J. S Duncan and L. H. Staib, IEEE Transaction on Medical Imaging, 22(12):1505-1518, 2003.
  

"Anatomic Dissection Tractography: A New Method for Precise MR Localization of White Matter Tracts", E. L. Kier, L. H. Staib, L. M. Davis and R. A. Bronen, AJNR Amer. J. Neuroradiology, 25:670-676, 2004. (see accompanying editorial: 25:667-668). " MR Imaging of the Temporal Stem: Anatomic Dissection Tractography of the Uncinate Fasciculus, Inferior Occipitofrontal Fasciculus, and Meyer's Loop of the Optic Radiation", E. L. Kier, L. H. Staib, L. M. Davis, and R. A. Bronen, AJNR Amer. J. Neuroradiology, 25:677-691, 2004 (see accompanying editorial: 25:667-668).

• "Geometric strategies for neuroanatomical analysis from MRI" (pdf), J. Duncan, X. Papademetris, J. Yang, M. Jackowski, X. Zeng, and L. H. Staib. NeuroImage, 23:S34--S45, 2004.
  
  
• "Estimation of anatomical connectivity by anisotropic front propagation and diffusion tensor imaging" (pdf), M. Jackowski, C. Y. Kao, M. Qiu, R. T. Constable, and L. H. Staib. In C. Barillot, D. R. Haynor, and P. Hellier, editors, Medical Image Computing and Computer-Assisted Intervention, page 663-671. Part II, LNCS 3217, Springer, 2004.
  
  
• "Integrating intensity and feature nonrigid registration", X. Papademetris, L. H. Staib, A. P. Jackowski, L. Y. Win, R. T. Schultz, and J. S. Duncan", In C. Barillot, D. R. Haynor, and P. Hellier, editors, Medical Image Computing and Computer-Assisted Intervention, pages 763--770. Part I, LNCS 3216, Springer, 2004.
  
  
• "Functional Brain Image Analysis Using Joint Function-Structure Priors (pdf) ", J. Yang , X. Papademetris, L. H. Staib, R. T. Schultz and J. S. Duncan, In C. Barillot, D. R. Haynor, and P. Hellier, editors, Medical Image Computing and Computer-Assisted Intervention, page 736-744. Part II, LNCS 3217, Springer, 2004.
  
  
• "Correcting nonuniformities in MRI intensities using entropy minimization based on an elastic model", R. Bansal, L. H. Staib and B. S. Peterson, In C. Barillot, D. R. Haynor, and P. Hellier, editors, Medical Image Computing and Computer-Assisted Intervention, page 78-86. Part II, LNCS 3217, Springer, 2004.
  
  
• "Neighbor-constrained segmentation with level set based 3D deformable models (pdf)", J. Yang, L. H. Staib, and J. S. Duncan. IEEE Trans. Med. Imaging, 23(8):940-948, 2004.
  
  
• "ROC Based Statistical Analysis of 3D Cortical Surface Matching Algorithms (pdf)", R. Bansal, L. H. Staib , R. Whiteman, Y. M. Wang and B. S. Peterson, Neuroimage, 2005.
  
  
• X. Papademetris, P. Shkarin, L. H. Staib, K. Behar, Regional Whole Body Fat Quantification in Mice, Information Processing in Medical Imaging, LNCS 3565, pp. 369-380, 2005.
  
  
• M. Jackowski, C. Y. Kao, R. T. Constable, M. Qiu and L. H. Staib, White matter tractography by Anisotropic Wavefront Evolution and Diffusion Tensor Imaging, Medical Image Analysis, 9(5):427-440, 2005.
  
  
• X. Papademetris, D. P. Dione, L. W. Dobruki, L. H. Staib, A. J. Sinusas, Articulated Rigid Registration for Serial Lower-Limb Mouse Imaging, Medical Image Computing and Computer-Assisted Intervention (MICCAI), LNCS 3750, 919-926, 2005.
  
  
• M. Jackowski, X. Papademetris, L. W. Dobruki, A. J. Sinusas, L. H. Staib, Characterizing Vascular Connectivity from microCT images, Medical Image Computing and Computer-Assisted Intervention (MICCAI), LNCS 3750, 701-708, 2005.
  
  
• X. Papademetris, K. P. Vives, M. DiStasio, L. H. Staib, M. Neff, S. Flossman, N. Frielinghaus, H. Zaveri, E. J. Novotny, H. Blumenfeld, R. T. Constable, H. P. Hetherington, R. B. Duckrow, S. S. Spencer, D. D. Spencer, J. S. Duncan, Development of a Research Interface for Image Guided Intervention: Initial Application to Epilepsy Neurosurgery, IEEE Int. Symp. Biomedical Imaging (ISBI), pages 490-493, 2006.
  
  
• S. Li, K. Mueller, M. Jackowski, D. P. Dione and L. H. Staib, Fast Marching Method to Correct for Refraction in Ultrasound Computed Tomography, IEEE Int. Symp. Biomedical Imaging (ISBI), pages 896-899, 2006.
  
  
• L. H. Staib, M. Jackowski, X. Papademetris, Shape characterization from deformation, IEEE Int. Symp. Biomedical Imaging (ISBI), pages 1140-1143, 2006.
  
  
• X. Papademetris, M. P. Jackowski, N. Rajeevan, M. DiStasio, H. Okuda, R. T. Constable and L. H. Staib, BioImage Suite: An Integrated medical image analysis suite: An update, MICCAI Open Source Workshop, The Insight Journal, 2006.
  
  
• R. Bansal, L. H. Staib, D. Xu, H. Zhu, B. S. Peterson, Statistical Analyses of Brain Surfaces Using Gaussian Random Fields on 2D Manifolds, IEEE Transactions on Medical Imaging, 26(1):46-57, 2007.
  
  
• R. Bansal, L. H. Staib, K. Plessen, D. Xu, J. Royal, B. S. Peterson, Voxel-wise Comparisons of the Morphology of Diffusion Tensors across Groups of Experimental Subjects, Psychiatry Research: Neuroimaging, Psychiatry Research: Neuroimaging, 156(3):225-245 2007.
  
  
• S. Li, K. Mueller, M. Jackowski, D. P. Dione and L. H. Staib, Refraction Corrected Ultrasound Computed Tomography with FMM-SART: Physically-based Phantom Experiments, IEEE Medical Imaging and Nuclear Science Conference, 2007.
  
  
• A. P. Jackowski, H. Douglas-Palumberi, M. Jackowski, L. Win, R. T. Schultz, L. H. Staib, J. H. Krystal, J. Kaufman, Corpus Callosum in Maltreated Children with PTSD: A Diffusion Tensor Imaging Study, Psychiatry Research: Neuroimaging, 162(3):256-261, Apr 2008.
  
  
• C. DeLorenzo, X. Papademetris, L. H. Staib, K. Vives, D. Spencer, J. Duncan, Nonrigid Intraoperative Cortical Surface Tracking Using Game Theory, Mathematical Methods in Biomedical Image Analysis, 2007.
  
  
• R. Bansal L. H. Staib, D. Xu, A. F. Laine, J. Royal, B. S. Peterson, Using Perturbation Theory to Compute the Morphological Similarity of Diffusion Tensors, IEEE Transactions on Medical Imaging, 27(5):589-607, 2008.
  
  
• W. H. Greene, S. Chelikani, X. Papademetris, L. H. Staib, J. Kniseley, and J. S. Duncan, Tracking organ overlap for a constrained non-rigid registration algorithm, IEEE Int. Symp. Biomedical Imaging (ISBI), pages 1159-1162, 2008.
  
  
• R. Bansal, L. H. Staib, A. F. Laine, D. Xu, J. Liu, J. Royal, B. S. Peterson, Calculation of the Confidence Region for Transformation Parameters in the Registration of Medical Images, Medical Image Analysis, 2008 (in press).
  
  
• D. R. Bathula, X. Papademetris, L. H. Staib, R. T. Schultz, J. S. Duncan, Analysis of functional MRI data with ICA, MICCAI 2008.
  
  
• W. H. Greene, S. Chelikani, X. Papademetris, L. H. Staib, J. Kniseley, and J. S. Duncan, A Constrained Non-rigid Registration Algorithm for use in Prostate Image-guided radiotherapy, MICCAI 2008.
  
  
• S. Li, K. Mueller, L. H. Staib, M. Jackowski, D. Dione, Physical-Space Refraction-Corrected Transmission Ultrasound Computed Tomography Made Computationally Practical, MICCAI 2008.
  
  
• A. Joshi, D. Scheinost, K. Vives, D. Spencer, L. H. Staib and X. Papademetris, Novel Interaction Techniques for Neurosurgical Planning and Stereotactic Navigation, IEEE Visualization, 2008.
  
  
• L. G. Chepenik, C. Fredericks, X. Papademetris, L. Spencer, C. Lacadie, F. Wang, B. Pittman, J. S. Duncan, L. H. Staib, R. S. Duman, J. Gelernter, H. P. Blumberg, Effects of the Brain Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder, Neuropsychopharmacology, 2008.
  
  
• E. Kahn and L. H. Staib, Image Registration with Automatic Computation of Gradients (pdf), (Insight Link) The Insight Journal, 2008.
  
  

B. Kelley, N. Harel, C. Kim, X. Papademetris, D. Coman, X. Wang, O. Hasan, A. Kaufman, R. Globinsky, L. H. Staib, W. Cafferty, F. Hyder, S. Strittmatter, Diffusion tensor imaging as a predictor of locomotor function after experimental spinal cord injury and recovery. Journal of Neurotrauma, 31(15):1362-1373, 2014.

Old Links

MMBIA (Mathematical Methods in Biomedical Image Analysis) 2001

CVIU Nonrigid Registration Special Issue (2003)

MICCAI '05 Tutorials

Lawrence Staib
Department of Radiology & Biomedical Imaging
Yale University School of Medicine
P. O. Box 208042
333 Cedar Street, New Haven, CT 06520-8042 USA
Ph: 203-785-2427